Review



sr57227 hydrochloride  (Bio-Techne corporation)


Bioz Verified Symbol Bio-Techne corporation is a verified supplier
Bioz Manufacturer Symbol Bio-Techne corporation manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 92
      Buy from Supplier

    Structured Review

    Bio-Techne corporation sr57227 hydrochloride
    Sr57227 Hydrochloride, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 92/100, based on 15 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sr+57227+hydrochloride/pm36651645-99-20-25?v=Bio-Techne+corporation
    Average 92 stars, based on 15 article reviews
    sr57227 hydrochloride - by Bioz Stars, 2026-07
    92/100 stars

    Images



    Similar Products

    sr57227 hydrochloride  (Bio-Techne corporation)
    92
    Bio-Techne corporation sr57227 hydrochloride
    Sr57227 Hydrochloride, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sr+57227+hydrochloride/pm36651645-99-20-25?v=Bio-Techne+corporation
    Average 92 stars, based on 1 article reviews
    sr57227 hydrochloride - by Bioz Stars, 2026-07
    92/100 stars
    		  Buy from Supplier
    sr57227 hydrochloride  (Santa Cruz Biotechnology)
    93
    Santa Cruz Biotechnology sr57227 hydrochloride
    Sr57227 Hydrochloride, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sr+57227+hydrochloride/10__1523_slash_eneuro__0352___25__2025-72-11-30?v=Santa+Cruz+Biotechnology
    Average 93 stars, based on 1 article reviews
    sr57227 hydrochloride - by Bioz Stars, 2026-07
    93/100 stars
    		  Buy from Supplier
    sr57227 hydrochloride sr  (Tocris)
    92
    Tocris sr57227 hydrochloride sr
    Sr57227 Hydrochloride Sr, supplied by Tocris, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sr+57227+hydrochloride/pm38448762-37-20-23?v=Tocris
    Average 92 stars, based on 1 article reviews
    sr57227 hydrochloride sr - by Bioz Stars, 2026-07
    92/100 stars
    		  Buy from Supplier
    tcs 1205  (Tocris)
    93
    Tocris tcs 1205
    Tcs 1205, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sr+57227+hydrochloride/pmc06650745-72-3-10?v=Tocris
    Average 93 stars, based on 1 article reviews
    tcs 1205 - by Bioz Stars, 2026-07
    93/100 stars
    		  Buy from Supplier
    sr57227  (Tocris)
    93
    Tocris sr57227
    Fig. 4 Activation of hindbrain 5-HT3R suppresses chow intake and is dependent on central GLP-1 signaling. The 5-HT3R agonist, <t>SR57227</t> <t>(SR5)</t> was delivered (4th ICV) using the following doses: 0 (aCSF), 5, 10, or 20 µg a–c (n = 11). Only the highest dose (20 µg) of SR5 suppresses chow intake, this suppression was significant at all timepoints. a A 20 µg treatment with SR5(4th ICV) prevents BW gain seen in the control group b and increases kaolin intake c (n = 21). The effect of central blockade of GLP-1Rs was tested in a separate cohort (n = 19). Treatment with Ex9 reverses the anorectic effect of SR5 at 6 and 24 h, but not at 1 and 3 h d (n = 19). SR5 and Ex9 alone or in combination have no effect on 24 h body weight e or kaolin intake f. A repeated measures one-way ANOVA and Dunnet post hoc (*p < 0.05, **p < 0.01) was used in 3a, whereas a paired t test was used for b–c. Data in d–f were analyzed using a two-way ANOVA, different letters are significantly different from each other (p < 0.05) according to Newman–Keuls post hoc analyses
    Sr57227, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sr+57227+hydrochloride/pm30959513-44-29-31?v=Tocris
    Average 93 stars, based on 1 article reviews
    sr57227 - by Bioz Stars, 2026-07
    93/100 stars
    		  Buy from Supplier
    sr57227 hydrochloride  (Tocris)
    92
    Tocris sr57227 hydrochloride
    Fig. 4 Activation of hindbrain 5-HT3R suppresses chow intake and is dependent on central GLP-1 signaling. The 5-HT3R agonist, <t>SR57227</t> <t>(SR5)</t> was delivered (4th ICV) using the following doses: 0 (aCSF), 5, 10, or 20 µg a–c (n = 11). Only the highest dose (20 µg) of SR5 suppresses chow intake, this suppression was significant at all timepoints. a A 20 µg treatment with SR5(4th ICV) prevents BW gain seen in the control group b and increases kaolin intake c (n = 21). The effect of central blockade of GLP-1Rs was tested in a separate cohort (n = 19). Treatment with Ex9 reverses the anorectic effect of SR5 at 6 and 24 h, but not at 1 and 3 h d (n = 19). SR5 and Ex9 alone or in combination have no effect on 24 h body weight e or kaolin intake f. A repeated measures one-way ANOVA and Dunnet post hoc (*p < 0.05, **p < 0.01) was used in 3a, whereas a paired t test was used for b–c. Data in d–f were analyzed using a two-way ANOVA, different letters are significantly different from each other (p < 0.05) according to Newman–Keuls post hoc analyses
    Sr57227 Hydrochloride, supplied by Tocris, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sr+57227+hydrochloride/pm28647281-53-23-31?v=Tocris
    Average 92 stars, based on 1 article reviews
    sr57227 hydrochloride - by Bioz Stars, 2026-07
    92/100 stars
    		  Buy from Supplier
    57227 hydrochloride  (Tocris)
    92
    Tocris 57227 hydrochloride
    Fig. 4 Activation of hindbrain 5-HT3R suppresses chow intake and is dependent on central GLP-1 signaling. The 5-HT3R agonist, <t>SR57227</t> <t>(SR5)</t> was delivered (4th ICV) using the following doses: 0 (aCSF), 5, 10, or 20 µg a–c (n = 11). Only the highest dose (20 µg) of SR5 suppresses chow intake, this suppression was significant at all timepoints. a A 20 µg treatment with SR5(4th ICV) prevents BW gain seen in the control group b and increases kaolin intake c (n = 21). The effect of central blockade of GLP-1Rs was tested in a separate cohort (n = 19). Treatment with Ex9 reverses the anorectic effect of SR5 at 6 and 24 h, but not at 1 and 3 h d (n = 19). SR5 and Ex9 alone or in combination have no effect on 24 h body weight e or kaolin intake f. A repeated measures one-way ANOVA and Dunnet post hoc (*p < 0.05, **p < 0.01) was used in 3a, whereas a paired t test was used for b–c. Data in d–f were analyzed using a two-way ANOVA, different letters are significantly different from each other (p < 0.05) according to Newman–Keuls post hoc analyses
    57227 Hydrochloride, supplied by Tocris, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sr+57227+hydrochloride/pmc04263148-163-9-13?v=Tocris
    Average 92 stars, based on 1 article reviews
    57227 hydrochloride - by Bioz Stars, 2026-07
    92/100 stars
    		  Buy from Supplier

    Image Search Results


    Fig. 4 Activation of hindbrain 5-HT3R suppresses chow intake and is dependent on central GLP-1 signaling. The 5-HT3R agonist, SR57227 (SR5) was delivered (4th ICV) using the following doses: 0 (aCSF), 5, 10, or 20 µg a–c (n = 11). Only the highest dose (20 µg) of SR5 suppresses chow intake, this suppression was significant at all timepoints. a A 20 µg treatment with SR5(4th ICV) prevents BW gain seen in the control group b and increases kaolin intake c (n = 21). The effect of central blockade of GLP-1Rs was tested in a separate cohort (n = 19). Treatment with Ex9 reverses the anorectic effect of SR5 at 6 and 24 h, but not at 1 and 3 h d (n = 19). SR5 and Ex9 alone or in combination have no effect on 24 h body weight e or kaolin intake f. A repeated measures one-way ANOVA and Dunnet post hoc (*p < 0.05, **p < 0.01) was used in 3a, whereas a paired t test was used for b–c. Data in d–f were analyzed using a two-way ANOVA, different letters are significantly different from each other (p < 0.05) according to Newman–Keuls post hoc analyses

    Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    Article Title: Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation.

    doi: 10.1038/s41386-019-0384-x

    Figure Lengend Snippet: Fig. 4 Activation of hindbrain 5-HT3R suppresses chow intake and is dependent on central GLP-1 signaling. The 5-HT3R agonist, SR57227 (SR5) was delivered (4th ICV) using the following doses: 0 (aCSF), 5, 10, or 20 µg a–c (n = 11). Only the highest dose (20 µg) of SR5 suppresses chow intake, this suppression was significant at all timepoints. a A 20 µg treatment with SR5(4th ICV) prevents BW gain seen in the control group b and increases kaolin intake c (n = 21). The effect of central blockade of GLP-1Rs was tested in a separate cohort (n = 19). Treatment with Ex9 reverses the anorectic effect of SR5 at 6 and 24 h, but not at 1 and 3 h d (n = 19). SR5 and Ex9 alone or in combination have no effect on 24 h body weight e or kaolin intake f. A repeated measures one-way ANOVA and Dunnet post hoc (*p < 0.05, **p < 0.01) was used in 3a, whereas a paired t test was used for b–c. Data in d–f were analyzed using a two-way ANOVA, different letters are significantly different from each other (p < 0.05) according to Newman–Keuls post hoc analyses

    Article Snippet: Drugs and delivery sites The competitive GLP-1R antagonist, exendin-(9–39) (Ex9; Bachem, 4017799), serotonin chloride (5-HT; Tocris, 3547), selective 5- HT2CR agonist, lorcaserin (Lor; KeyOrganics, KS1439), and selective 5-HT3R agonist, SR57227 (SR5; Tocris, 1205), were all dissolved in artificial cerebrospinal fluid (aCSF; Harvard Apparatus, 59–7316).

    Techniques: Activation Assay, Control